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Related Experiment Videos

Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to

M Krstevska-Konstantinova1, C Charlier, M Craen

  • 1Division of Ambulatory Pediatrics and Adolescent Medicine, Department of Pediatrics and Laboratory of Toxicology, University of Liège, C.H.U. Sart Tilman, Liège, Belgium.

Human Reproduction (Oxford, England)
|May 2, 2001
PubMed
Summary
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Foreign children immigrating to Belgium showed higher levels of p,p'-DDE, a DDT metabolite, correlating with precocious puberty. This suggests environmental endocrine disruptors may trigger early sexual development in susceptible populations.

Area of Science:

  • Endocrinology
  • Environmental Health
  • Pediatrics

Background:

  • Precocious puberty is a condition characterized by early onset of puberty.
  • A significant percentage of children treated for precocious puberty in Belgium were foreign immigrants.
  • Previous deprivation was not evident in immigrant children with precocious puberty.

Purpose of the Study:

  • To investigate the potential role of environmental endocrine disruptors in the development of precocious puberty among immigrant children.
  • To explore the association between pesticide exposure and early sexual maturation.

Main Methods:

  • Retrospective auxological study of 145 patients.
  • Toxicological plasma screening for eight pesticides, focusing on p,p '-DDE.
  • Comparison of p,p '-DDE concentrations between foreign immigrant and native Belgian girls with precocious puberty.

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Main Results:

  • p,p '-DDE was detected in foreign adopted and non-adopted girls with precocious puberty.
  • Median p,p '-DDE concentrations were significantly higher in foreign girls compared to native Belgian girls.
  • Native Belgian girls with idiopathic or organic precocious puberty mostly showed undetectable p,p '-DDE levels.

Conclusions:

  • Transient exposure to endocrine-disrupting chemicals, specifically p,p '-DDE, may be linked to sexual precocity in immigrant children.
  • Further research is warranted to confirm the relationship between endocrine disruptors and precocious puberty in this population.
  • This finding highlights the importance of environmental factors in pediatric endocrine disorders.