Quantitative cytomorphologic analyses of Papanicolaou-stained smears from oral lichen planus
N Mollaoglu1, J G Cowpe, R Walker
1Department of Oral Surgery, Medicine and Pathology, University of Wales College of Medicine and Dental School, Cardiff. nurm@ada.net.tr
Objective:
To apply quantitative techniques to cytologic smears in order to improve the diagnostic sensitivity of cytology in the detection of malignant change in the oral cavity.
Study Design:
Eighty-two patients with lesions of oral lichen planus were investigated. A total of 247 Papanicolaou-stained buccal smears underwent nuclear and cytoplasmic area measurements using a TV image analyzer.
Results:
The cytomorphologic results of this study suggest that lesions of oral lichen planus contain smaller cells and nuclei than those observed in clinically normal oral mucosal smears. There was a statistically significant reduction in nuclear area (P < .001) and cytoplasmic area (P < .05) for the oral lichen planus smears.
Conclusion:
The TV image analysis system could provide a valuable method of quantifying cell changes in oral smears collected from oral mucosa as a method of monitoring lesions of oral lichen planus.
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