[Effect of estrogen on hemodynamics and vascular remodeling with Takayasu arteritis]

This study utilized Takayasu arteritis (TA) model to do the experiment in order to observe the remodeling of arterial geometry. Plasma estrogen, progesterone and products of nitrous oxide (NO2- and NO3-) were examined. Qualitative analyses of maximum (MAX), minimum (MIN) and mean (MEAN) velocity of blood flow, resistant index (PI), pulsatile index (PI), and shear stress (SS) of abdominal aorta were performed. The results showed that plasma estrogen, progesterone and products of nitrous oxide were respectively 1137.80 +/- 189.30 pg.ml-1, 14.10 +/- 1.61 micrograms.ml-1 and 195.78 +/- 53.01 mumol.L-1 in experiment group, whereas in control group, they were 34.74 +/- 10.20 pg.ml-1, 2.60 +/- 1.83 micrograms.ml-1 and 12.16 +/- 3.28 mumol.L-1 respectively, P < 0.01. In comparison of hemodynamic parameters of abdominal aorta, the MAX and MIN of experiment group were profoundly higher than those of control group. SS increased markedly in experiment group. The observation of arterial remodeling in vitro found wall thickening. The thickness of abdominal aortic wall and inside diameter of vessel cavity ratio (h/Di) was 0.6145 +/- 0.1654 in experiment group and 0.2151 +/- 0.0266 in control group, P < 0.01. The arterial collagen content in experimental group was significantly higher than that in control group. Hyperestrinemia gives rise to a series of hemodynamic alterations, influences vessel remodeling along with TA, and finally results in arterial stenosis, occlusion or aneurysms due to the constitutional composition of vascular wall reforming.