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Cord blood endothelin-1 and perinatal asphyxia
N Laforgia1, I Difonzo, M Altomare
1Dipartimento di Biomedicina dell'Età Evolutiva, Università degli Studi di Bari, Italy. n.laforgia@neonatologia.uniba.it
Acta Paediatrica (Oslo, Norway : 1992)
|May 3, 2001
Abstract
Unlabelled:
Discordant data have been reported on endothelin-1 (ET-1), a potent endothelium-derived vasoconstriction peptide, during the neonatal period, and elevated levels have been found in various neonatal diseases. This study evaluated ET-1 in the cord blood of 74 neonates of different gestational age, birthweight, mode of delivery and 5'-Apgar score.
Conclusion:
Higher ET-1 levels were found in neonates born by emergency caesarean section, and in newborns with low 5'-Apgar score, suggesting that ET-1 could be a marker of perinatal asphyxia.