[A case of multiple intracranial cavernous angiomas presented with dementia and parkinsonism--clinical and MRI study...

We report a case of multiple intracranial cavernous angiomas with serial clinical examination and with MRI imaging for 10 years. The patient, 72 years old woman, had slowly progressive postural tremor and Parkinsonism followed by dementia. Pathological confirmation of cavernous angioma was obtained. At the age of 62, brain MRI study demonstrated hydrocephalus, multiple small hypointensity dots in cerebellum and cerebral white matter, and reticulated cores predominantly adjacent to the ventricles on T2-weighted images. Serial MRI imaging shows that the number of small dots has markedly increased and that hypointense lesions surrounding reticulated core, corresponding to hemosidern deposit, have extended. This case indicates that probably due to chronic compression and continuous hemorrhage' multiple and long-standing intracranial lesions could cause dementia and Parkinsonism, which are uncommon symptoms of cavernous angioma.