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[Sweet's syndrome].

M Chakroun1, F Ben Romdhane, W B Mohamed

  • 1Service des Maladies Infectieuses, CHU Monastir.

La Tunisie Medicale
|May 3, 2001
PubMed
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Sweet's syndrome, or acute febrile neutrophilic dermatosis, often requires biopsy for diagnosis when antibiotics fail. Colchicine proved effective in most cases, highlighting its therapeutic potential.

Area of Science:

  • Dermatology
  • Rheumatology
  • Pathology

Context:

  • Sweet's syndrome (acute febrile neutrophilic dermatosis) is a recognized dermatosis.
  • It can manifest independently or as a secondary condition linked to various systemic diseases, including autoimmune disorders and malignancies.
  • This retrospective analysis focuses on a cohort of patients diagnosed with Sweet's syndrome.

Purpose:

  • To retrospectively analyze 10 cases of Sweet's syndrome diagnosed over a 42-month period.
  • To evaluate diagnostic criteria, clinical presentation, and treatment outcomes.
  • To underscore the diagnostic value of skin biopsy for refractory papulonodular lesions.

Summary:

  • The study identified a female predominance (9:1) with a mean age of 45 years.

Related Experiment Videos

  • Lesions predominantly affected the legs (9 cases).
  • Diagnosis was confirmed via clinical, biological, and histological findings. Antibiotics were ineffective in all patients, while colchicine showed efficacy in 6 cases.

    • Impact:

    • Highlights the importance of skin biopsy for diagnosing papulonodular lesions unresponsive to antibiotics.
    • Suggests colchicine as a potentially effective treatment for Sweet's syndrome.
    • Contributes to understanding the clinical characteristics and management of this condition.