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Maternal serum levels of type I and type III procollagen peptides in pre-eclamptic pregnancy

H Yamamoto1, G M Lambert-Messerlian, H M Silver

  • 1Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Japan.

The Journal of Maternal-Fetal Medicine
|May 3, 2001
PubMed

Insights

Maternal serum levels of procollagen I carboxy-terminal peptide (PICP) and procollagen III amino-terminal peptide (PIIINP) were elevated in pre-eclampsia patients. However, these collagen markers are unlikely to predict pre-eclampsia.

Area of Science:

  • Obstetrics and Gynecology
  • Biochemistry
  • Maternal-Fetal Medicine

Background:

  • Pre-eclampsia is a serious pregnancy complication.
  • Collagen synthesis markers may be altered in pre-eclampsia.

Purpose of the Study:

  • To compare maternal serum levels of PICP and PIIINP in pre-eclampsia patients versus controls.
  • To assess the predictive value of these markers for pre-eclampsia.

Main Methods:

  • Radioimmunoassay was used to measure PICP and PIIINP in maternal serum.
  • Study included patients with pre-eclampsia (n=37 for PICP, n=12 for PIIINP) and controls (n=36 for PICP, n=19 for PIIINP) at ≥32 weeks' gestation.

Main Results:

  • Both PICP and PIIINP levels were significantly higher in pre-eclampsia patients compared to controls.
  • PICP levels were 20% higher and PIIINP levels were 80% higher on average in cases.

Conclusions:

  • Maternal serum PICP and PIIINP levels are mildly elevated in pre-eclampsia.
  • These markers are not considered useful for predicting pre-eclampsia.
Abstract

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