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APOE polymorphism in a rural older population-based sample in India.

B K Thelma1, R C Juyal, H H Dodge

  • 1Department of Genetics, University of Delhi South Campus, New Delhi, India.

Human Biology
|May 3, 2001
PubMed
Summary
This summary is machine-generated.

This study reports apolipoprotein E (APOE) allele frequencies in a large, representative Indian population. The APOE*4 allele frequency was found to be exceptionally low, providing crucial genetic data.

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Area of Science:

  • Genetics
  • Population Genetics
  • Human Genetics

Background:

  • Allele frequencies are typically reported from small, non-representative samples, limiting generalizability.
  • Understanding genetic variations like apolipoprotein E (APOE) genotype is crucial for population health studies.
  • There is a need for reliable genetic data from diverse populations, including India.

Purpose of the Study:

  • To determine the distribution of apolipoprotein E (APOE) genotype and allele frequencies in a large, representative, rural, population-based sample in Haryana, India.
  • To provide a demographic breakdown of APOE allele frequencies by age, sex, and religious/caste groups.
  • To establish a normative genetic background for future gene-disease association studies in the Indian population.

Main Methods:

  • Genotyping of the apolipoprotein E (APOE) polymorphism in a sample of 4450 individuals aged 55-95 years.
  • Utilizing a well-defined, representative, rural, population-based cohort from Ballabgarh, Haryana, India.
  • Analysis of allele frequencies (E*2, E*3, E*4) and their distribution across demographic subgroups.

Main Results:

  • The overall allele frequencies for APOE E*2, E*3, and E*4 were 0.039, 0.887, and 0.073, respectively.
  • The APOE*4 allele frequency (0.073) is among the lowest reported globally.
  • APOE allele frequencies showed no significant variation by age or sex within this study population.

Conclusions:

  • This study presents the largest Indian sample genotyped for APOE polymorphism to date.
  • The findings provide a valuable, representative genetic dataset for the North Indian population.
  • The low APOE*4 frequency has implications for understanding population-specific genetic risk factors and disease associations.