Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antigen specific immunotherapy of multiple sclerosis.

L Steinman1, P Conlon

  • 1Department of Neurological Science, Stanford University, California 94305, USA. steinman@stanford.edu

Journal of Clinical Immunology
|May 3, 2001
PubMed
Summary

Antigen specific therapy shows promise for multiple sclerosis (MS) by targeting the immune response to myelin. This approach aims to suppress harmful autoimmunity while preserving overall immune function, with further research into minimizing side effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic polymorphism in <i>Methylenetetrahydrofolate Reductase chloride transport protein 6</i> (<i>MTHFR CLCN6</i>) gene is associated with keratinocyte skin cancer in a cohort of renal transplant recipients.

Skin health and disease·2022
Same author

Influence of Various Factors on Circulating 25(OH) Vitamin D Concentrations in Dogs with Cancer and Healthy Dogs.

Journal of veterinary internal medicine·2017
Same author

High-risk cutaneous malignancies and immunosuppression: Challenges for the reconstructive surgeon in the renal transplant population.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2017
Same author

The influence of inhaled anesthetic and body temperature on serum fentanyl concentrations with transdermally administered fentanyl in anesthetized dogs.

Veterinary anaesthesia and analgesia·2017
Same author

Clinical manifestations of prune belly syndrome.

Clinical medicine (London, England)·2016
Same author

The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice.

Clinical and experimental immunology·2016

Area of Science:

  • Neuroimmunology
  • Autoimmune disease therapy

Background:

  • Multiple sclerosis (MS) involves immune responses targeting the myelin sheath and axon.
  • Current therapeutic strategies aim to modulate the immune system's activity.

Purpose of the Study:

  • To explore antigen-specific therapy for multiple sclerosis.
  • To investigate the potential of altered peptide ligands in modulating autoimmune responses.
  • To achieve immune suppression while preserving overall immune function.

Main Methods:

  • Utilizing altered peptide ligands targeting key autoimmune response components in MS.
  • Investigating the induction of a Th1-to-Th2 immune shift.
  • Assessing and minimizing potential side effects like allergic responses through optimal dosing.

Related Experiment Videos

Main Results:

  • Demonstrated success with altered peptide ligands in targeting MS-related autoimmune responses.
  • Identified antigen-specific therapy as a potential method to suppress undesirable autoimmunity.
  • Highlighted the possibility of preserving the intact immune system.

Conclusions:

  • Antigen-specific therapy, particularly using altered peptide ligands, offers a promising approach for multiple sclerosis treatment.
  • Inducing an antigen-specific Th1-to-Th2 shift is a viable strategy for managing MS.
  • Further optimization is needed to minimize side effects for clinical application.