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Updated: Aug 4, 2026

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Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization
Published on: July 10, 2017
Quantifying DNA damage by gel electrophoresis, electronic imaging and number-average length analysis
J C Sutherland1, D C Monteleone, J G Trunk
1Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. jcs@bnl.gov
Electrophoresis
|May 3, 2001
Abstract:
DNA damages that can be converted to single- or double strand breaks can be quantified by separating DNA by gel electrophoresis and obtaining a quantitative image of the resulting distribution of DNA in the gel. We review the theory of this method and discuss its implementation, including the charge-coupled device (CCD) camera systems we developed to acquire images of fluorophore labeled DNA.

