Biotransformation of drugs: quantitative structure-activity relationships for barbiturates, tertiary amines, and

|November 1, 1976

Abstract:

When using free energy-related physicochemical parameters, stimulation of NADPH oxidation by barbiturates and the N-oxidation of tertiary amines was found to be primarily dependent upon the lipophilic character of the substrates as measured by log P, where P is the partition coefficient from either 1-octanol-water or corn oil-water solvent systems. In contrast, the inhibition of epoxidation of aldrin by a series of substituted imidazoles appears to be much more dependent on electronic (sigma) and steric (Es) effects of the inhibitors.

Related Concept Videos

Articles linked to this work by shared authors, journal, and citation graph.

Anomalous line shape of the cross section for e{+}e{-}--> hadrons in the center-of-mass energy region between 3.650 and 3.872 GeV.

Physical review letters·2008

Measurements of the continuum R(uds) and R values in e(+)e(-) annihilation in the energy region between 3.650 and 3.872 GeV.

Physical review letters·2007

Search for invisible decays of eta and eta' in J/psi --> phi eta and phi eta'.

Physical review letters·2006

See all related articles

Related Experiment Videos

Biotransformation of drugs: quantitative structure-activity relationships for barbiturates, tertiary amines, and

Related Concept Videos

Anomalous line shape of the cross section for e{+}e{-}--> hadrons in the center-of-mass energy region between 3.650 and 3.872 GeV.

Search for the invisible decay of J/psi in psi(2S) --> pi(+)pi(-) J/psi.

Observation of Y(2175) in J/psi --> etaphif0 (980).

Measurement of psi2S radiative decays.

Measurements of the continuum R(uds) and R values in e(+)e(-) annihilation in the energy region between 3.650 and 3.872 GeV.

Search for invisible decays of eta and eta' in J/psi --> phi eta and phi eta'.

The shake-test for adjuvanted vaccines: A manufacturer's perspective.

Development of novel pH-responsive liposomes composed of anionic lipids and pH-sensitive cationic lipids for efficient drug release in weakly acidic environments.

At-line estimation of powder lubrication using rotating drum: Linking specific volume kinetics to tensile strength loss.

Intranasal delivery of sertraline hydrochloride enhanced brain concentration and antidepressant activity: A comparative pharmacokinetic and pharmacodynamic study.

A novel approach to unified compaction curve model for improved tabletability prediction of virtual roller compacted formulations.

Physiologically based pharmacokinetic modeling for methotrexate in cerebrospinal fluid in humans.

Pharmacodynamics of Boronic Acids and Boronates.

Transdermal buprenorphine in low-dose induction strategies for opioid use disorder: a case report and systematic review.

Comparative pharmacotherapeutic efficacy and dose-related safety profiles of intrathecal baclofen: a systematic review and meta-analysis in neurological spasticity.

Outpatient Direct Initiation of Injectable Buprenorphine From Methadone: A Case Series.

Discovery of bioactive peptides from Arbacia lixula as dipeptidyl peptidase-IV inhibitors: An in silico approach.

Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics and the Pharmacokinetics of Balcinrenone When Dosed with a P-gp Inhibitor.

Related Experiment Videos

Biotransformation of drugs: quantitative structure-activity relationships for barbiturates, tertiary amines, and...

Abstract:

Related Concept Videos

Related Articles

Biotransformation of drugs: quantitative structure-activity relationships for barbiturates, tertiary amines, and