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Updated: Jan 20, 2026
Neurostimulation System Setup and Symptom Collection for Personalized Treatment of Depression
Published on: June 17, 2025
The association between depressive symptoms and cognitive decline in community-dwelling elderly persons
H C Comijs1, C Jonker, A T Beekman
1Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7-9, 1081 BT Amsterdam, The Netherlands. h.comijs.emgo@med.vu.nl
Objective:
To investigate whether depressive symptoms predict specific types of cognitive decline in order to elucidate the association between late life depression and cognitive decline.
Background:
Mechanisms underlying the association between late life depression and cognitive decline are still unclear.
Method:
Six hundred and forty-one elderly persons of the Longitudinal Aging Study Amsterdam (LASA) aged 70-85 were examined by means of two measurement occasions over a period of 3 years. Depressive symptoms were assessed by means of the CES-D. Various cognitive functions were examined using neuropsychological tests.
Results:
Depressive symptoms were associated with decline in speed of information processing over a 3-year period, whereas there was no association between depression and increasing memory impairment or global mental deterioration.
Conclusion:
These findings suggest that depressive symptoms are associated with subcortical pathology, most probable white matter lesions.
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