Related Experiment Video
Updated: Oct 7, 2026

A Pre-Clinical Model of Synovitis Using Ex vivo Human Synovial Tissue with Preserved Function and Architecture
Published on: March 20, 2026
[Reactive arthritis shortly after Streptococcus b-hemolyticus type A and Salmonella type B infection]
J Gómez Carrasco1, A Carrasco Torres, P Sevilla Ramos
1Servicio de Pediatría. Hospital Universitario Príncipe de Asturias, Madrid. jgomez@hupa.insalud.es
Abstract:
We report the case of a girl aged 2 years and 8 months with monoarticular arthritis of the knee. Onset and outcome were slow. The child had suffered uncomplicated pharyngitis and a diarrheal process 1 and 2 weeks respectively prior to developing the disease. Additional data suggested the presence of reactive arthritis after Streptococcus infection. Salmonella was also detected in the feces. Unlike rheumatic fever, post-streptococcus reactive arthritis does not follow Jones' criteria and the clinical course is slow. Because gastrointestinal infection with both Streptococcus and Salmonella occurred simultaneously, the interaction between both agents, each of which alone can cause reactive arthritis, might have produced a synergic action in our patient.
Related Concept Videos
Rheumatic Heart Disease I: Introduction
Hypersensitivity Reactions: Immune-Complex Reactions
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Streptococcal Pharyngitis
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Rheumatic Heart Disease III: Medical Management