Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Baclofen overdose in two siblings.

D Chapple1, D Johnson, R Connors

  • 1Department of Pediatrics, Faculty of Medicine, University of Calgary, Alberta, Canada.

Pediatric Emergency Care
|May 4, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variations in selective nerve root block technique.

Annals of the Royal College of Surgeons of England·2015
Same author

Augmentation of hypoxic pulmonary vasoconstriction by N(G)-L-methyl-arginine in a rabbit model of thermal injury.

The American journal of emergency medicine·1996
Same author

Counseling to reduce road injuries and deaths.

Canadian family physician Medecin de famille canadien·1996
Same author

Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44.

The Journal of clinical investigation·1996
Same author

Unusual features of osteoarticular tuberculosis in children.

The Journal of pediatrics·1996
Same author

A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae.

Cell·1996

Baclofen overdose in children is rare but serious, causing severe respiratory depression. Parents should be warned about baclofen toxicity risks, especially when the drug is prescribed within a family.

Area of Science:

  • Pharmacology
  • Pediatric Medicine
  • Neurology

Background:

  • Baclofen is a widely used muscle relaxant for managing spasticity in neuromuscular disorders.
  • Few cases of baclofen overdose have been documented in pediatric populations.
  • This study focuses on baclofen overdose in siblings, highlighting a critical knowledge gap.

Observation:

  • Two siblings experienced severe respiratory depression after baclofen exposure.
  • Both children required mechanical ventilation due to respiratory compromise.
  • Significantly elevated serum baclofen levels were detected in both affected children.

Findings:

  • The reported cases represent a significant instance of baclofen overdose in pediatric patients.
  • Literature review confirms the rarity but severity of baclofen overdose in children and adolescents.

Related Experiment Videos

  • Elevated serum concentrations correlate with severe clinical manifestations.

    • Implications:

    • Healthcare providers must educate parents on the potential toxicity of baclofen.
    • Vigilance is crucial when prescribing baclofen, particularly in households with multiple children.
    • Understanding baclofen's overdose profile is essential for prompt diagnosis and management in pediatric emergencies.