Related Experiment Video

Updated: Oct 7, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

Glomerular growth under cyclosporine treatment in childhood nephrotic syndrome

H J Jeong1, J H Kim, P K Kim

  • 1Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. jeong10@yumc.yonsei.ac.kr

Clinical Nephrology
|May 4, 2001
PubMed

Insights

Cyclosporine (CsA) treatment in children with nephrotic syndrome can hinder glomerular growth, potentially leading to kidney damage. Impaired growth is linked to treatment duration and tubulointerstitial lesions (TIL).

Area of Science:

  • Pediatric Nephrology
  • Renal Pathology
  • Pharmacology

Background:

  • Glomerular hypertrophy is a key factor in pediatric idiopathic nephrotic syndrome (INS) pathogenesis and diagnosis.
  • Cyclosporine (CsA) is used to treat INS, but its effect on glomerular growth is not fully understood.

Purpose of the Study:

  • To investigate the impact of CsA treatment on glomerular growth in children with INS.
  • To assess the relationship between glomerular morphometry, treatment duration, and adverse renal outcomes.

Main Methods:

  • Morphometric analysis of Bowman's area (BA) and glomerular tuft area (GA) in pre- and post-treatment kidney biopsies from 47 children with INS (MCD and FSGS).
  • Patients received CsA and low-dose prednisolone for up to 2 years.

Main Results:

  • Glomerular areas (BA and GA) increased with age and were larger in FSGS compared to MCD.
  • CsA treatment led to a decrease in BA and GA in a significant proportion of patients (48.9% and 40.4%, respectively).
  • Development of tubulointerstitial lesions (TIL) was observed in 27.7% of cases, with greater glomerular area reduction in these children.

Conclusions:

  • CsA treatment can impair glomerular growth in children with INS, a complication more frequent than TIL.
  • The degree of glomerular growth impairment is associated with treatment duration and the presence of TIL.
  • Age and specific diagnosis (MCD vs. FSGS) did not influence the impairment of glomerular growth.
Abstract

More Related Videos

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...