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Updated: Aug 3, 2026

Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
Insulin and somatostatin releasing islet cell tumor caused hypoglycemia
Y Karasawa1, T Mochizuki, S Kawa
1Department of Internal Medicine 2, Shinshu University Medical School, Matsumoto.
Abstract:
We report a hypoglycemic case with normal insulin levels, which was caused by an islet cell tumor that was releasing insulin and somatostatin. A fasting test suggested the over secretion of insulin. Moreover, this hypoglycemia was enhanced by the inhibitory effect of somatostatin on the secretion of insulin counter-regulatory hormones, such as glucagon, in addition to the autonomous secretion of insulin from the tumor. In cases of hypoglycemia with apparently normal insulin levels, the measurement of somatostatin and various provocative tests are recommended. Arterial stimulation venous sampling (ASVS) was useful to detect the location of this functioning islet cell tumor.
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