Parametric studies on the phase shift method to measure the blood perfusion of biological bodies

To better understand the phase shift method to non-invasively measure the blood perfusion of living tissues in vivo, the dual reciprocity boundary element method (DRBEM) was applied to numerically solve the transient and non-linear two-dimensional bio-heat transfer in biological bodies subject to a sinusoidal heat flux at the skin surface. The influences of the heating flux, the heating oscillation magnitude, the heating frequency, the blood vessel underneath the skin, and the space or temperature dependent blood perfusion to the temperature response and the phase shift between the heat flux and the temperature response at the skin surface were comprehensively examined. The effects of the heating area to the temperature response were also investigated. And a better understanding on the heat transfer behavior of biological bodies under sinusoidal heating was thus obtained. These results are expected to be valuable for constructing the practical instrumentation to non-invasively measure the blood perfusion of biological bodies.