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A prospective randomized trial comparing clomiphene citrate with tamoxifen citrate for ovulation induction
R Boostanfar1, J K Jain, D R Mishell
1Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.
Objective:
To compare the rates of ovulation and pregnancy after tamoxifen citrate (TMX) or clomiphene citrate (CC) among anovulatory women with infertility.
Design:
Prospective randomized trial.
Setting:
Infertility clinic in a university teaching hospital.
Patient(S):
Eighty-six anovulatory women under 40 years of age undergoing ovulation induction.
Intervention(S):
The women were assigned randomly to receive either TMX or CC on cycle days 5-9.
Main Outcome Measure(S):
Rates of ovulation and pregnancy for the two treatment modalities.
Results(S):
The overall rate of ovulation in the TMX group was 50 of 113 (44.2%) and in the CC group, 41 of 91 (45.1%). There were 10 pregnancies in the TMX group and 6 pregnancies in the CC group. The cycle fecundity per ovulatory cycle was 20.0% in the TMX group and 14.6% in the CC group.
Conclusion(S):
The overall rate of ovulation and pregnancy were similar with TMX and CC. TMX is a suitable alternative agent to CC in the management of anovulatory infertility.