Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Parasite genome initiatives.

W M Degrave1, S Melville, A Ivens

  • 1DBBM - IOC/Fiocruz, Av. Brasil 4365, Manguinhos, 21045-900, Rio de Janeiro, Brazil. wdegrave@dbbm.fiocruz.br

International Journal for Parasitology
|May 4, 2001
PubMed
Summary

International collaborations launched parasite genome projects, focusing on mapping and sequencing Plasmodium falciparum and other pathogens. These initiatives are advancing to post-genomics analysis and bioinformatics for disease research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Whole Blood Profiling of T-cell-Derived microRNA Allows the Development of Prognostic models in Inflammatory Bowel Disease.

Journal of Crohn's & colitis·2020
Same author

The Value of Radiology in Some Intrathoracic Diseases.

Postgraduate medical journal·2011
Same author

X Rays in the Diagnosis of Intrathoracic Growths.

British medical journal·2010
Same author

RADIOLOGY IN DISEASES OF THE LUNGS.

British medical journal·2010
Same author

Age dependent incorporation of 14C-DHA into rat brain and body tissues after dosing various 14C-DHA-esters.

Prostaglandins, leukotrienes, and essential fatty acids·2010
Same author

Demonstration of a New Tube-stand.

Proceedings of the Royal Society of Medicine·2009

Area of Science:

  • Genomics and Bioinformatics
  • Parasitology and Tropical Diseases

Background:

  • Initiated in 1993-1994, international parasite genome projects emerged from existing scientific collaborations.
  • Funding from organizations like WHO/TDR and Wellcome Trust supported mapping and sequencing of key parasitic organisms.

Purpose of the Study:

  • To establish consortiums for mapping and sequencing medium-sized parasitic genomes.
  • To facilitate gene discovery and understand the genetic makeup of important human pathogens.

Main Methods:

  • Genome mapping and sequencing of various parasites, including Plasmodium falciparum, Schistosoma mansoni, and Trypanosoma species.
  • Development of genomic resources such as expressed sequence tags (ESTs) and various library constructions (BAC, YAC).
  • Initiation of post-genomics studies including proteomics, functional analysis, and microarray analysis.

Related Experiment Videos

Main Results:

  • Successful establishment of mapping and sequencing efforts for multiple pathogenic parasite genomes.
  • Transition from initial gene discovery to large-scale genome sequencing and subsequent post-genomics research.
  • Expansion of bioinformatics networks, including those in developing countries, for data analysis and annotation.

Conclusions:

  • Parasite genome projects have progressed significantly from mapping to comprehensive sequencing and post-genomics.
  • International collaboration and dedicated funding have been crucial for advancing this research.
  • Enhanced bioinformatics capabilities are essential for interpreting complex genomic data and driving future research.