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Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
Published on: October 14, 2021
Increased response to visual feedback of drug-induced dyskinetic movements in advanced Parkinson's disease
X Liu1, R Osterbauer, T Z Aziz
1University Laboratory of Physiology, Parks Road, OX1 3PT, Oxford, UK. xl@physiol.ox.ac.uk
Abstract:
To investigate the response to visual feedback of involuntary movements which have a frequency composition similar to cerebellar tremor but are not caused by cerebellar damage, we have tested six advanced Parkinson's disease (PD) patients with drug-induced dyskinetic movements using visually guided wrist tracking tasks. Tracking performance was assessed under three visual conditions: (1) both guiding target and movement cursor were displayed continuously; (2) the target display was turned off for the second half of each trial; or (3) the cursor display, but not the target, was turned off for the second half of each trial. The response to visual feedback of drug-induced dyskinetic movements at 1-5 Hz in these advanced PD patients were significantly increased than in normal controls. This suggests that increased response to visual feedback might be a common feature of low frequency involuntary movements and not directly caused by cerebellar damages.
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