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Related Experiment Videos

Bacteremic infection with Pediococcus: vancomycin-resistant opportunist.

L L Barton1, E D Rider, R W Coen

  • 1Department of Pediatrics and Steele Memorial Children's Research Center, University of Arizona, Tucson, AZ 85724-5073, USA. llb@peds.arizona.edu

Pediatrics
|May 23, 2001
PubMed
Summary

Pediococci are emerging Gram-positive pathogens causing severe infections in vulnerable patients. This study highlights a case of Pediococcus infection in an infant with gastroschisis, suggesting a potential link to probiotic use.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pediatrics

Background:

  • Pediococci, Gram-positive bacteria, are increasingly recognized as human pathogens.
  • These bacteria exhibit resistance to vancomycin and susceptibility to penicillin.
  • Infections are documented in adults with comorbidities and post-abdominal surgery, and in infants with gastrointestinal malformations.

Observation:

  • A case of a third infant with gastroschisis is presented.
  • The infant developed Pediococcus bacteremia and meningitis three months post-surgery.

Findings:

  • Pediococcus species can cause severe invasive infections, including bacteremia and meningitis, in infants with surgical histories.
  • The specific strain and its potential virulence factors require further investigation.

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Implications:

  • This case underscores the need for vigilance regarding Pediococcus infections in immunocompromised infants and those with gastrointestinal anomalies.
  • The potential role of probiotics in the pathogenesis of Pediococcus infections warrants further research.