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Bacteremic infection with Pediococcus: vancomycin-resistant opportunist
L L Barton1, E D Rider, R W Coen
1Department of Pediatrics and Steele Memorial Children's Research Center, University of Arizona, Tucson, AZ 85724-5073, USA. llb@peds.arizona.edu
Abstract:
Pediococci are recently recognized Gram-positive human pathogens, resistant to vancomycin and generally susceptible to penicillin. Infection in adults has been seen in patients with chronic underlying conditions as well as those with previous abdominal surgery. Two previous infants with congenital gastrointestinal malformations requiring surgical correction have been reported with sepsis attributable to Pediococcus sp. We report a third infant born with gastroschisis who developed Pediococcus bacteremia and meningitis 3 months after surgery, and speculate regarding the role of probiotics in the pathogenesis of this infection.
Insights
Pediococci are emerging Gram-positive pathogens causing severe infections in vulnerable patients. This study highlights a case of Pediococcus infection in an infant with gastroschisis, suggesting a potential link to probiotic use.
Area of Science:
- Microbiology
- Infectious Diseases
- Pediatrics
Background:
- Pediococci, Gram-positive bacteria, are increasingly recognized as human pathogens.
- These bacteria exhibit resistance to vancomycin and susceptibility to penicillin.
- Infections are documented in adults with comorbidities and post-abdominal surgery, and in infants with gastrointestinal malformations.
Observation:
- A case of a third infant with gastroschisis is presented.
- The infant developed Pediococcus bacteremia and meningitis three months post-surgery.
Findings:
- Pediococcus species can cause severe invasive infections, including bacteremia and meningitis, in infants with surgical histories.
- The specific strain and its potential virulence factors require further investigation.
Implications:
- This case underscores the need for vigilance regarding Pediococcus infections in immunocompromised infants and those with gastrointestinal anomalies.
- The potential role of probiotics in the pathogenesis of Pediococcus infections warrants further research.