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Asthma from diisocyanates is not mediated through a Type IV, patch-test-positive mechanism
L Kanerva1, T Estlander, R Jolanki
1Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FIN-00250 Helsinki, Finland.
Contact Dermatitis
|May 5, 2001
Abstract:
The mechanism of occupational asthma from diisocyanates (DI)(1-10)(Fig. 1) is not fully known; only about 10%-30% of such patients have specific IgE antibodies to DI (3, 11, 12). A T-cell mediated response has been considered to be involved in DI asthma (13) and we therefore wondered whether patch testing might be of any help in its diagnosis.