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Related Experiment Videos

Experience of ApoE study in Thai elderly.

V Senanarong1, K Harnphadungkit, P Lertrit

  • 1Department of Medicine, Faculty of Medicine Siriraj Hospital,Mahidol University, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|May 5, 2001
PubMed
Summary

The apolipoprotein E (ApoE) E4 gene significantly increases dementia risk in Thai elderly. ApoE genotyping can aid in diagnosing Alzheimer's disease.

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Area of Science:

  • Genetics
  • Neurology
  • Gerontology

Background:

  • The apolipoprotein E (ApoE) E4 allele is linked to dementia, including Alzheimer's disease and multi-infarct dementia.
  • Understanding ApoE genotype distribution and its association with dementia in diverse populations is crucial for public health.

Purpose of the Study:

  • To investigate the association between apolipoprotein E (ApoE) genotype and dementia in the elderly Thai population.
  • To determine the allele frequencies of ApoE in a Thai cohort.

Main Methods:

  • A case-control study involving 78 dementia patients and 94 controls aged over 50.
  • Dementia diagnosis was based on DSM IV criteria.
  • ApoE genotyping was performed using DNA extraction and restriction enzyme analysis, with statistical analysis using SPSS 9.0.

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Main Results:

  • Allele frequencies in controls were ApoE E2 (0.03), E (0.80), E4 (0.17). In dementia subjects, frequencies were E3 (0.71) and E4 (0.29).
  • The odds ratio for dementia risk was 0.62 for ApoE E3 and 1.98 for ApoE E4.
  • Among 42 Alzheimer's disease subjects, 59.5% carried the ApoE E4 allele, with a positive predictive value of 0.60.

Conclusions:

  • The ApoE genotype distribution in Thai elderly is comparable to other ethnic groups.
  • Carrying the ApoE E4 gene is associated with an increased risk of developing dementia.
  • ApoE genotyping serves as a valuable diagnostic adjunct for Alzheimer's disease.