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Effects of hypertonic saline solution on mesenteric microcirculation.

I P Torres Filho1, D Contaifer Junior, S Garcia

  • 1Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, UERJ, Rio de Janeiro, RJ, Brasil.

Shock (Augusta, Ga.)
|May 5, 2001
PubMed
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Hypertonic saline partially restored blood pressure and microvascular flow in hemorrhaged rats by increasing arteriolar vasomotion. It did not affect normovolemic animals, suggesting specific resuscitation mechanisms.

Area of Science:

  • Physiology
  • Pharmacology
  • Resuscitation Medicine

Background:

  • Hemorrhagic hypotension poses significant physiological challenges.
  • Understanding microvascular responses is crucial for effective resuscitation strategies.

Purpose of the Study:

  • To evaluate the systemic and microvascular effects of hypertonic saline in normovolemic and hemorrhaged rats.
  • To investigate the impact of hypertonic saline on arteriolar vasomotion during hypotension.

Main Methods:

  • Intravital microscopy was used to measure arteriolar and venular diameters and red blood cell velocity in Wistar rats.
  • Systemic parameters including mean arterial pressure and heart rate were monitored.
  • Animals underwent a hypotension protocol followed by infusion of normal or hypertonic saline.

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Main Results:

  • Hypertonic saline partially restored mean arterial pressure and microvascular blood flow in hemorrhaged rats.
  • Arteriolar vasomotion increased significantly in frequency and amplitude after hypertonic saline infusion during hypotension.
  • No significant systemic or microvascular effects were observed in normovolemic animals treated with hypertonic saline.

Conclusions:

  • Hypertonic saline may improve resuscitation outcomes during hemorrhagic hypotension by modulating arteriolar vasomotion.
  • The observed microvascular effects of hypertonic saline are specific to the hypotensive state.