Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxygen therapeutics--current concepts.

S E Hill1

  • 1Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA. hill0012@mc.duke.edu

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|May 5, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Public understandings of potential policy responses to health inequalities: Evidence from a UK national survey and citizens' juries in three UK cities.

Social science & medicine (1982)·2021
Same author

Retrospective, epidemiological cluster analysis of the Middle East respiratory syndrome coronavirus (MERS-CoV) epidemic using open source data.

Epidemiology and infection·2017
Same author

Is local alcohol outlet density related to alcohol-related morbidity and mortality in Scottish cities?

Health & place·2015
Same author

Institutional response to FDA warning on aprotinin and impact on outcomes.

HSR proceedings in intensive care & cardiovascular anesthesia·2013
Same author

Physicochemical properties and nutritional quality of raw cereals for newly weaned piglets.

Animal : an international journal of animal bioscience·2012
Same author

Physicochemical changes to starch granules during micronisation and extrusion processing of wheat, and their implications for starch digestibility in the newly weaned piglet.

Animal : an international journal of animal bioscience·2012
Same journal

Comment on: Brachial plexus block at the level of the humeral head: a proof-of-concept observational cadaver and clinical study.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same journal

In reply: Comment on: Brachial plexus block at the level of the humeral head: a proof-of-concept observational cadaver and clinical study.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same journal

Effects of acupoint stimulation for postoperative analgesia after Cesarean delivery: a systematic review and meta-analysis of randomized controlled trials.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same journal

Tracheal ochronosis.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same journal

Association between lactate clearance rate and 28-day mortality in patients with sepsis: a retrospective cohort study and exploration of an optimal lactate clearance as an endpoint of resuscitation.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same journal

Lactate clearance in patients with septic shock: identifying the point of diminishing returns.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
See all related articles

New blood substitutes, including perfluorocarbon emulsions and modified hemoglobin solutions, show promise for enhancing oxygen delivery without transfusion risks. Further development may lead to ideal oxygen therapeutic agents.

Area of Science:

  • Biomedical Engineering
  • Pharmacology
  • Hematology

Background:

  • Allogeneic blood transfusions carry inherent risks.
  • Development of artificial oxygen carriers aims to mitigate these risks.
  • Two main classes of oxygen therapeutics are under investigation: perfluorocarbon (PFC) emulsions and modified hemoglobin solutions.

Purpose of the Study:

  • To review the development and clinical trial status of novel oxygen therapeutic agents.
  • To assess the potential of these agents as alternatives to blood transfusions.

Main Methods:

  • Literature review of studies on oxygen therapeutic agents.
  • Analysis of development pathways and clinical trial data for PFCs and hemoglobin-based oxygen carriers (HBOCs).

Related Experiment Videos

Main Results:

  • Perfluorocarbon (PFC) emulsions increase dissolved oxygen and enhance delivery, with two products in Phase III trials.
  • Hemoglobin-based oxygen carriers (HBOCs), including cross-linked or microencapsulated hemoglobin, aim to improve oxygen release and reduce toxicity.
  • Four HBOC products have undergone Phase III clinical trials, utilizing human, bovine, or recombinant hemoglobin.

Conclusions:

  • Oxygen therapeutics demonstrate promising oxygen-carrying capacity and acceptable side effect profiles in preliminary studies.
  • No oxygen therapeutic agent has yet received regulatory approval for clinical use.
  • Future research may focus on hybrid products combining the strengths of different oxygen carrier designs.