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Intralymphatic Immunotherapy and Vaccination in Mice
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Published on: February 2, 2014

Intravenous immunoglobulin therapy for the treatment of severe atopic dermatitis

S R Lamb1, M Rademaker

  • 1Dermatology Department, Health Waikato, Private Bag 3200, Hamilton, New Zealand.

Expert Opinion on Pharmacotherapy
|May 5, 2001
PubMed

Intravenous immunoglobulin (IVIg) is standard therapy for primary immunodeficiencies, Kawasaki Disease and idiopathic thrombocytopenic purpura. More recently, the use of high dose IVIg (2 g/kg in divided doses) has widened to include a number of inflammatory diseases, including atopic eczema. The mechanism of IVIg's anti-inflammatory action has yet to be fully understood. Proposed mechanisms include modulation of IgE responses and a reduction in inflammatory cytokines with a reduction in T-cell proliferation. Antibacterial and antitoxin effects may also play a role.

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