Related Experiment Video
Updated: Aug 2, 2026
08:35
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Amlodipine/benazepril: fixed dose combination therapy for hypertension
1Creighton University School of Pharmacy and Allied Health Professions, 2500 California Plaza, Omaha, Nebraska 68178, USA. faulkner@creighton.edu
Expert Opinion on Pharmacotherapy
|May 5, 2001
Summary
Fixed-dose combination therapy, such as amlodipine/benazepril, offers significant advantages for managing hypertension. This approach improves blood pressure control, adherence, and cost-effectiveness compared to monotherapy.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Uncontrolled hypertension leads to severe health issues like heart attack, stroke, and kidney disease.
- Blood pressure control remains suboptimal for many patients, often requiring multiple medications.
Purpose of the Study:
- To evaluate the efficacy and safety of fixed-dose combination amlodipine/benazepril for hypertension management.
- To highlight the benefits of combination therapy over monotherapy.
Main Methods:
- Review of clinical trial data for amlodipine/benazepril.
- Comparison of adverse event rates and adherence with monotherapy and placebo.
Main Results:
- Amlodipine/benazepril demonstrates substantial blood pressure lowering capabilities.
- Adverse event rates are comparable to placebo, with minimal impact from occasional dose omission.
- Combination therapy shows sustained 24-hour blood pressure control.
Conclusions:
- Fixed-dose amlodipine/benazepril is an effective option for patients needing more than one antihypertensive medication.
- This combination offers improved adherence, safety, and cost-effectiveness.
- Consider amlodipine/benazepril for patients whose hypertension is not adequately controlled by monotherapy.
More Related Videos
Related Concept Videos
01:01Dosage Regimen: Fixed Dose
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
01:30Antihypertensive Drugs: Angiotensin II Receptor Blockers
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
01:25Antihypertensive Drugs: Direct Renin Inhibitors
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
01:28Hypertension IV: Drug Therapy and Lifestyle Modifications
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...