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Updated: Oct 7, 2026

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
Published on: May 5, 2022
Disinhibition of somatosensory and motor cortex in mitochondriopathy without myoclonus
J Liepert1, J Haueisen, S Hegemann
1Department of Neurology, Friedrich Schiller University of Jena, Jena, Germany. liepert@uke.uni-hamburg.de
Objective:
To test electrophysiologically, if patients with mitochondriopathy but without evidence of myocloni have subclinical signs of disinhibition in motor and somatosensory cortices.
Methods:
Two patients were studied and compared with age-matched control groups.
Results:
In both patients, giant somatosensory evoked potentials after median nerve stimulation and a reduced intracortical inhibition tested by transcranial magnetic stimulation in a paired pulse paradigm indicated a dysfunction of inhibitory circuits in the motor as well as the somatosensory cortex. In addition, the somatosensory evoked 600 Hz activity recorded by magnetoencephalography was abolished.
Conclusions:
Patients with mitochondriopathy may suffer from a subclinical disturbance of inhibition in the sensorimotor cortex. The loss of 600 Hz activity indicates that these high-frequency oscillations could reflect the activity of inhibitory neurons in the somatosensory cortex.
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