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Related Experiment Videos

Programmable biodegradable implants.

W Vogelhuber1, P Rotunno, E Magni

  • 1Department of Pharmaceutical Technology, University of Regensburg, 93040, Regensburg, Germany.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|May 5, 2001
PubMed
Summary
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New pulsatile release implants offer controlled drug delivery for up to 58 days. These tiny, biocompatible devices can be programmed for timed substance release, aiding vaccination and tumor therapy.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Controlled drug release is crucial for effective therapies, minimizing side effects and improving patient compliance.
  • Existing drug delivery systems often lack precise temporal control over substance release.
  • Biodegradable polymers offer potential for developing advanced implantable devices.

Purpose of the Study:

  • To develop and characterize pulsatile release implants capable of controlled drug delivery over extended periods.
  • To investigate the influence of polymer properties on the onset and duration of drug release.
  • To demonstrate the feasibility of programmable, timed drug release for therapeutic applications.

Main Methods:

  • Fabrication of pulsatile release implants using biodegradable polymers (polyanhydrides, poly(D,L-lactic acid), poly(D,L-lactic acid-co-glycolic acid)).

Related Experiment Videos

  • Characterization of implant dimensions, drug loading capacity, and release profiles.
  • In vivo testing using a nude mouse model to assess drug release onset and visual observation of substance release (Evan's blue).
  • Correlation of polymer properties (molecular weight, end-group chemistry) with drug release kinetics.

    • Main Results:

    • Developed implants releasing substances up to 58 days post-implantation with precise control over release onset.
    • Demonstrated that polymer degradation (bulk eroding poly(D,L-lactic acid) and copolymers) dictates the timing of drug release.
    • Identified polymer molecular weight and carboxylic acid end-group state as key factors influencing release onset time.
    • Successfully visualized in vivo drug release using Evan's blue in a subcutaneous nude mouse model.

    Conclusions:

    • Pulsatile release implants offer a novel platform for programmable, time-controlled drug delivery.
    • The ability to combine matrices with different release profiles enables sophisticated therapeutic systems.
    • Potential applications include vaccination and localized tumor therapy, leveraging precise drug administration timing.