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Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress
S C Coste1, S E Murray, M P Stenzel-Poore
1Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR, USA.
Peptides
|May 5, 2001
Abstract:
This review highlights new information gained from studies using recently developed animal models that harbor specific alterations in corticotropin-releasing hormone (CRH) pathways. We discuss features of a transgenic mouse model of chronic CRH overexpression and two mouse models that lack either CRH receptor type 1 (CRH-R1) or type 2 (CRH-R2). Together these models provide new insights into the role of CRH pathways in promoting stability through adaptive changes, a process known as allostasis.