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Related Experiment Videos

Characterization of the hydroxypropylmethylcellulose-nicotinamide binary system.

T Hino1, J L Ford

  • 1School of Pharmacy and Chemistry, James Parsons Building, Liverpool John Moores University, Byrom Street, L3 3AF, Liverpool, UK.

International Journal of Pharmaceutics
|May 5, 2001
PubMed
Summary

Hydroxypropylmethylcellulose (HPMC) addition significantly alters nicotinamide's thermal properties. Higher HPMC concentrations reduce nicotinamide crystallinity and melting points, indicating significant interactions and potential for new material formulations.

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Area of Science:

  • Materials Science
  • Physical Chemistry
  • Polymer Science

Background:

  • Nicotinamide is a crucial pharmaceutical ingredient.
  • Understanding its thermal behavior with excipients is vital for drug formulation.
  • Hydroxypropylmethylcellulose (HPMC) is a common pharmaceutical excipient.

Purpose of the Study:

  • To investigate the impact of hydroxypropylmethylcellulose (HPMC) on the thermal behavior of nicotinamide.
  • To characterize the phase behavior and interactions between nicotinamide and HPMC.
  • To explore potential new material properties arising from nicotinamide-HPMC mixtures.

Main Methods:

  • Preparation of binary mixtures of nicotinamide and HPMC at various weight fractions.
  • Thermal analysis using differential scanning calorimetry (DSC) during heating, cooling, and re-heating cycles.

Related Experiment Videos

  • Structural characterization using X-ray diffraction (XRD).
  • Investigation of intermolecular interactions using infrared (IR) spectroscopy.

    • Main Results:

    • HPMC dissolved in molten nicotinamide at 140°C.
    • Mixtures with X(HPMC) < 0.4 formed film structures upon cooling.
    • Nicotinamide crystallinity and melting peaks decreased with increasing HPMC content, disappearing around X(HPMC) ≈ 0.4.
    • Glass transition temperature (Tg) of the mixtures increased with HPMC concentration.
    • Inflections in enthalpy of melting and 1/Tg plots occurred around X(HPMC) = 0.37-0.38.
    • Infrared studies confirmed hydrogen bond formation between nicotinamide and HPMC.

    Conclusions:

    • HPMC significantly modifies the thermal behavior and crystallinity of nicotinamide.
    • Interactions, including hydrogen bonding, between HPMC and nicotinamide influence phase transitions.
    • The study reveals critical composition ranges for forming distinct material structures and properties.
    • Findings suggest potential for developing novel nicotinamide-HPMC based materials with tailored thermal characteristics.