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Cutaneous leucocytoclastic vasculitis associated with oxacillin
P Koutkia1, E Mylonakis, S Rounds
1Department of Endocrinology, Diabetes and Nutrition, Boston Medical Center, Boston University, 88 East Newton Street, Evans Building, Room #201, Boston, MA 02118, USA. Polyxeni.Koutkia@bmc.org
Diagnostic Microbiology and Infectious Disease
|May 5, 2001
Summary
Oxacillin can cause leucocytoclastic vasculitis, a condition presenting as palpable purpura and renal failure. Prompt corticosteroid treatment can resolve symptoms and restore renal function.
Area of Science:
- Nephrology
- Dermatology
- Rheumatology
Background:
- Antibiotic-induced adverse drug reactions are a significant clinical concern.
- Staphylococcus aureus bacteremia requires effective antibiotic treatment, such as oxacillin.
Observation:
- A 67-year-old male developed acute renal failure and palpable purpuric lesions on his feet after a week of oxacillin treatment for Staphylococcus aureus bacteremia.
- Skin biopsies confirmed leucocytoclastic vasculitis, characterized by necrotic blisters on the fingers.
Findings:
- Discontinuation of oxacillin and initiation of corticosteroid therapy led to the resolution of the rash within three weeks.
- The patient's renal function returned to normal following treatment, indicating a reversible drug-induced vasculitis.
Implications:
- Oxacillin should be recognized as a potential cause of leucocytoclastic vasculitis.
- Early recognition and management, including corticosteroid therapy, are crucial for preventing severe complications associated with drug-induced vasculitis.