Related Experiment Video

Updated: Sep 21, 2026

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography
06:53

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

Drying rates of tablet granulations II: effect of particle size and granular densities

W O Opankunle, B R Bhutani, V N Bhatia

    Journal of Pharmaceutical Sciences
    |June 1, 1975
    PubMed

    More Related Videos

    Formation of Dispersible Taohong Siwu Tablets05:44

    Formation of Dispersible Taohong Siwu Tablets

    Published on: February 3, 2023

    Disposable Dosators Intended for Dry Powder Delivery to Mice04:59

    Disposable Dosators Intended for Dry Powder Delivery to Mice

    Published on: August 18, 2023

    Related Concept Videos

    Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

    Factors Influencing Drug Absorption: Pharmaceutical Parameters

    Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
    Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

    Factors Affecting Dissolution: Particle Size and Effective Surface Area

    Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
    Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

    Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

    Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
    Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

    Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

    Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
    Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

    Modified-Release Drug Delivery Systems: Rate-Programmed II

    Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
    Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

    Modified-Release Drug Delivery Systems: Rate-Programmed I

    Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...