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Timed-release tablets containing quinine sulfate.

N H Choulis, H Papadopoulos

Journal of Pharmaceutical Sciences

|June 1, 1975

Summary

This study investigated quinine sulfate release from timed-release tablets. Tablet formulation and compaction pressure significantly influenced drug release rates, crucial for controlled drug delivery.

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Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Timed-release drug delivery systems aim to control the rate of medication release.
Quinine sulfate is an antimalarial drug with a narrow therapeutic index, necessitating controlled release.

Purpose of the Study:

To evaluate the effect of formulation variables and compaction pressure on quinine sulfate release from slowly eroding tablets.
To characterize the dissolution profiles of novel timed-release tablet formulations.

Main Methods:

Tablets were prepared using varying amounts of swellable gum, carbomer, and cellulose acetate hydrogen phthalate.
Compaction pressure was systematically altered during tablet manufacturing.
Dissolution testing followed the National Formulary (NF) XIII method.
Quinine sulfate concentration was quantified using spectrophotometry.

Main Results:

The release rates of quinine sulfate were successfully determined for all tested formulations.
Variations in swellable gum, carbomer, cellulose acetate hydrogen phthalate content, and compaction pressure demonstrated an impact on drug release kinetics.
Slow erosion of the tablet matrix was observed, contributing to sustained release.

Conclusions:

Formulation composition and compaction pressure are critical parameters for controlling quinine sulfate release from slowly eroding, timed-release tablets.
The developed tablet formulations show potential for achieving desired drug release profiles in controlled drug delivery applications.

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