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Published on: October 30, 2015
Receptor measurements via Tc-GSA kinetic modeling are proportional to functional hepatocellular mass
1Department of Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Unlabelled:
Kinetic modeling of 99mTc-diethylenetriaminepentaacetic acid galactosyl human serum albumin (Tc-GSA) measures the total amount of asialoglycoprotein receptor within a subject's liver. This study tested the hypothesis that the amount of asialoglycoprotein receptor measured by Tc-GSA modeling provides a valid index of functional liver mass.
Methods:
Twenty-two patients with cirrhosis, 18 patients with chronic hepatitis, and 9 patients with normal liver parenchyma were studied with Tc-GSA using a 30-min dynamic imaging protocol. The total amount of hepatic receptor was measured by kinetic modeling of the Tc-GSA time-activity data. The total number of viable hepatocytes was calculated using standard morphometric measurements of liver biopsy samples and liver volume measurements through CT.
Results:
The total receptor amount strongly correlated with the total hepatocyte number (r = 0.803; P < 0.0001).
Conclusion:
Tc-GSA measurement of the total receptor amount is proportional to the number of viable hepatocytes and therefore provides a valid assessment of functional liver mass.
