Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Free radical damage in nasal polyp tissue.

H Doğru1, N Delibaş, F Döner

  • 1ENT-Head and Neck Surgery Department and Biochemistry Department, Süleyman Demirel University, School of Medicine, Isparta, Turkey. mutuz@hotmail.com

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|May 5, 2001
PubMed
Summary

Nasal polyp tissue shows elevated malondialdehyde (MDA) levels, indicating free radical (FR) injury. This suggests FRs play a role in the development of nasal polyps (NP).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigation of the Relationship Between Minor Salivary Gland Biopsy Findings and Pan-Immune-Inflammation Value (PIV) and Systemic Inflammation Response Index (SIRI).

Nigerian journal of clinical practice·2026
Same author

Genome-wide scanning for selection signatures in two autochthonous Anatolian chicken breeds.

British poultry science·2025
Same author

The importance of the incidental thyroid gland uptake during Tc-99m MIBI myocardial perfusion scintigraphy.

European review for medical and pharmacological sciences·2015
Same author

The role of prothrombotic factors in children with hemiplegic cerebral palsy.

Minerva pediatrica·2014
Same author

Serum levels of vitamin D, vitamin D-binding protein and vitamin D receptor in migraine patients from central Anatolia region.

International journal of clinical practice·2014
Same author

Effects of long-term fasting on female hormone levels: Ramadan model.

Clinical and experimental obstetrics & gynecology·2014

Area of Science:

  • Otorhinolaryngology
  • Pathophysiology
  • Biochemistry

Background:

  • Nasal polyps (NP) are benign growths in the nasal cavity.
  • The role of free radical (FR) injury in NP pathogenesis is not fully understood.

Purpose of the Study:

  • To investigate the presence of free radical injury in nasal polyp tissue.
  • To quantify malondialdehyde (MDA) levels as a marker of oxidative stress in NP.

Main Methods:

  • Prospective study involving 19 patients with nasal polyps.
  • Control specimens from 16 patients without sinonasal inflammatory conditions.
  • MDA levels measured using the Knudsen et al. method.

Main Results:

  • Mean MDA levels were significantly higher in nasal polyp specimens (38.2 ± 5.1) compared to control specimens (33.9 ± 1.6).

Related Experiment Videos

  • P < 0.01 indicated a statistically significant difference.

    • Conclusions:

    • Elevated MDA levels in NP tissue confirm the presence of FR-induced cell injury.
    • FRs are implicated in the multifactorial pathogenesis and life cycle of nasal polyps.