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Related Experiment Videos

Living donor lung transplantation.

R G Cohen1, V A Starnes

  • 1Department of Cardiothoracic Surgery, University of Southern California School of Medicine, USC Healthcare Consultation Center, 1510 San Pablo Street, No. 415, Los Angeles, California 90033, USA. rcohen@hsc.usc.edu

World Journal of Surgery
|May 8, 2001
PubMed
Summary

Living-donor lung transplants show acceptable outcomes, with 72% one-year survival. Donor safety is high, and recipients experience improved quality of life post-procedure.

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Area of Science:

  • Thoracic Surgery
  • Transplantation Medicine
  • Pulmonary Medicine

Background:

  • Living-donor lung transplantation (LDLT) has emerged as an alternative to cadaveric grafts.
  • Initially focused on rapidly deteriorating cystic fibrosis patients, indications have broadened.

Purpose of the Study:

  • To evaluate the outcomes and safety of living-donor bilateral lung transplantation.
  • To assess recipient survival, causes of mortality, rejection rates, and donor outcomes.

Main Methods:

  • Analysis of 101 living-donor bilateral lung transplants performed since 1993.
  • Review of donor lobectomy procedures (n=203) and recipient outcomes, including survival and quality of life.

Main Results:

  • One-year Kaplan-Meier recipient survival is 72%, with most deaths (76%) occurring within 2 months, primarily due to infection (62%).
  • Rejection incidence is low (0.8 episodes/patient), often mild and unilateral.
  • No donor mortality was reported; donors reported high quality of life post-donation.

Conclusions:

  • LDLT offers acceptable results for select patients with end-stage pulmonary disease.
  • Donor safety is excellent, with no reported mortality and high post-donation quality of life.
  • Recipient outcomes demonstrate the viability of LDLT, though infection remains a significant challenge.

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