Preparation and anticoagulant activity of trimethylsilyl heparin in Carbowax

Trimethylsilyl heparin, when administered intraduodenally or intragastrically to rats, did not increase intestinal absorption and, consequently, the clotting times were not influenced. However, suspension of sodium heparin in Carbowax 200 prolonged the whole blood clotting time at a dose of 50 mg/kg when given intraduodenally or intragastrically to rats.