Statistical advances in AIDS therapy trials
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1Department of Epidemiology and Biostatistics, School of Medicine BRB-G19, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4945, USA. jma13@po.cwru.edu
Abstract:
This paper reviews recent statistical advances in HIV/AIDS therapy trials. Our emphasis is on three emerging areas that address key challenges in AIDS research: the determination of optimal treatment sequences, estimating efficacy of intended treatment, and inference for repeated measures with dependent censoring. A common theme of these topics is the use of observational data within clinical trials to answer questions not addressed by the conventional intent-to-treat analysis. We also give a brief overview of some recent contributions to other topics relevant to AIDS clinical trials, including modelling of treatment compliance data, modelling of repeated measures, and group sequential testing.
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