Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Reproduction physiology and prostanoids].

K Tsuboi1, A Ichikawa

  • 1Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. ktsuboi@pharm.kyoto-u.ac.jp

Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|May 8, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic diversity of Lactobacillus delbrueckii isolated from raw milk in Hokkaido, Japan.

Journal of dairy science·2021
Same author

Evaluation of genotoxicity and subchronic toxicity of standardized rose hip extract.

Human & experimental toxicology·2017
Same author

Absolute configuration of sex pheromone for tea tussock moth,Euproctis pseudoconspersa (strand)via synthesis of (R)- and (S)-10, 14-dimethyl-1-pentadecyl isobutyrates.

Journal of chemical ecology·2013
Same author

In vitro immunization of human peripheral blood lymphocytes: establishment of B cell lines secreting IgM specific for cholera toxin B subunit from lymphocytes stimulated with IL-2 and IL-4.

Cytotechnology·2008
Same author

Molecular analysis of cross-reactive human monoclonal antibody AE6F4 generated by in vitro immunization: Epitope mapping of AE6F4 antibody on 14-3-3 family proteins and cytokeratin 8.

Cytotechnology·2008
Same author

Epitope analysis of human monoclonal antibody specific for rice allergenic protein generated by in vitro immunization.

Cytotechnology·2008
Same journal

Nihon yakurigaku zasshi. Folia pharmacologica Japonica·2026
Same journal

[Prediction of severe oral mucositis in cancer treatment: the role of the oral-gut axis in precision supportive care].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica·2026
Same journal

[Iron dysregulation and ferroptosis in heart failure: the dual faces of deficiency and overload].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica·2026
Same journal

[Pharmacological characteristics and clinical outcomes of Rimegepant (Nurtec<sup>®</sup> ODT), an oral CGRP receptor antagonist for the acute treatment and prevention of migraine].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica·2026
Same journal

[Pharmacological properties and clinical trial results of datopotamab deruxtecan (Dato-DXd, Datroway<sup>®</sup>)].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica·2026
Same journal

[Oxytocin regulates social familiarity-dependent mate choice in medaka].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica·2026
See all related articles

Prostanoids, crucial for female reproduction, are synthesized by cyclooxygenases (COXs). Research using gene-deficient mice clarifies the roles of specific prostaglandin (PG) isoforms in ovulation, fertilization, and parturition.

Area of Science:

  • Biochemistry
  • Reproductive Biology
  • Pharmacology

Context:

  • Prostanoids, including prostaglandins (PGs) and thromboxane, are lipid mediators derived from arachidonic acid via cyclooxygenase (COX) enzymes.
  • These compounds play diverse roles in physiological and pathological processes, with classical associations to female reproduction, pain, and fever.

Purpose:

  • To elucidate the specific roles of different prostaglandin-synthesizing enzymes (COX isoforms) and their receptors in key female reproductive events.
  • To utilize gene-deficient mouse models to precisely determine the contribution of each prostanoid pathway to ovulation, fertilization, and parturition.

Summary:

  • Late pregnancy parturition is critically dependent on PGF2 alpha synthesized by COX-1, acting via luteolysis.
  • COX-2 is implicated in producing uterotonic PGs essential for parturition, as evidenced by impaired delivery in PGF2 alpha receptor-deficient mice with altered COX-2 expression.

Related Experiment Videos

  • In early pregnancy, COX-2-derived PGE2, acting through the EP2 receptor, facilitates cumulus cell expansion, ovulation, and fertilization.

    • Impact:

    • Provides a clearer understanding of the molecular mechanisms governing female reproductive processes.
    • Offers insights for developing novel therapeutics targeting prostanoid pathways in reproductive medicine.
    • Aids in predicting and mitigating potential reproductive side effects of drugs used in non-reproductive contexts.