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[The state of antigen-dependent immunity system in children with chronic tonsillitis]

L E Ponomarev, R A Khanferian, O V Borovikov

    Vestnik Otorinolaringologii
    |May 8, 2001
    PubMed

    Insights

    Treatment for chronic tonsillitis in children showed positive immune system trends but some markers remained altered. Persistent immune alterations suggest potential genetic or autoimmune factors influencing recovery.

    Area of Science:

    • Immunology
    • Pediatrics
    • Infectious Diseases

    Context:

    • Chronic tonsillitis affects numerous children, impacting their immune status.
    • Decompensated tonsillitis presents complex immunological challenges in pediatric patients.
    • Health resort interventions offer a unique setting for studying chronic illness management.

    Purpose:

    • To evaluate the immunological changes in children with chronic tonsillitis before and after treatment.
    • To assess the effectiveness of health resort therapy on immune parameters in pediatric patients.
    • To identify potential underlying factors contributing to persistent immune dysregulation.

    Summary:

    • 245 children (7-14 years) with chronic tonsillitis underwent treatment.
    • Pre-treatment immune profiles showed low CD3+, CD4+/CD8+ ratios, high CD16+, low salivary IgA/SIgA, and high serum IgM.
    • Post-treatment, immune markers improved but CD16+, serum IgA, and salivary SIgA remained elevated compared to controls.

    Impact:

    • Treatment positively influenced key immune indicators in children with chronic tonsillitis.
    • Persistent immunological deviations suggest a role for genetic predisposition, autoimmune pathology, or chronic viral infections.
    • Findings highlight the need for further investigation into long-term immune management strategies for pediatric chronic tonsillitis.

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