Enantiomeric analysis of pharmaceutical compounds by ion/molecule reactions
1Department of Chemistry, University of California, Davis, California 95616, USA.
Abstract:
Protonated complexes involving cyclodextrin hosts and guest compounds that are pharmacologically important are produced in the gas phase and reacted with a gaseous amine. The guest is exchanged to produce a new protonated complex with the amine. The reaction is enantioselective and is used to develop a method for determining enantiomeric excess using only mass spectrometry. The pharmaceutical compounds include DOPA, amphetamine, ephedrine, and penicillamine. The presence of more than one reacting species is observed with DOPA and penicillamine. Molecular dynamics calculations are used to understand the nature of the interactions and the possible source of the variations in the reactivities.
Related Concept Videos
Ions, Molecules, and Compounds
Molecules and Compounds
Lewis Structures of Molecular Compounds and Polyatomic Ions
Precipitation of Ions
The equation that describes the equilibrium between solid calcium carbonate and its solvated ions is:
Precipitation Reactions
Common Ion Effect


