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Substituted phenoxyalkylpiperazines as dopamine D3 receptor ligands
1Laboratory of Molecular Pharmacology, Gedeon Richter Ltd., Budapest, Hungary. i.laszlovszky@richter.hu
Die Pharmazie
|May 8, 2001
Abstract:
A novel series of potential antipsychotic agents were prepared by combination of condensed heterocycles containing bridgehead nitrogen with (2-methoxyphenyl)piperazine using phenoxyalkyl spacer of variable length. The affinity of the compounds was determined at rat cloned D3 and rat D2, 5-HT1A receptors by an vitro receptor binding assay. The D3 selectivity of the compounds was calculated from the Ki values.