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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: Jul 26, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

Current treatment of osteosarcoma.

W S Ferguson1, A M Goorin

  • 1Division of Pediatric Hematology-Oncology, Rhode Island Hospital, 593 Eddy St., Providence, RI 02903, USA.

Cancer Investigation
|May 8, 2001
PubMed
Summary

Multidisciplinary care has improved osteosarcoma survival, with surgery and chemotherapy curing most patients. Further research is needed for high-risk groups, including those with metastatic disease.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Oncology

Background:

  • Osteosarcoma treatment has evolved significantly.
  • Multidisciplinary approaches have improved patient outcomes.
  • Historically, osteosarcoma had poor long-term survival rates.

Purpose of the Study:

  • To summarize current multidisciplinary treatment strategies for osteosarcoma.
  • To highlight advances in surgical and chemotherapeutic interventions.
  • To identify patient groups with poor prognoses and potential future research directions.

Main Methods:

  • Review of current surgical techniques for primary tumor excision.
  • Analysis of adjuvant and neoadjuvant chemotherapy regimens.
  • Discussion of radiation therapy's role in select cases.

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Related Experiment Videos

Last Updated: Jul 26, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Main Results:

  • At least two-thirds of osteosarcoma patients can now be cured.
  • Limb salvage surgery is a viable alternative to amputation for many.
  • High-dose methotrexate, doxorubicin, cisplatin, and ifosfamide/etoposide are key chemotherapy agents.

Conclusions:

  • Complete surgical excision and adjuvant chemotherapy are crucial for osteosarcoma management.
  • Patients with poor tumor necrosis after chemotherapy or with metastatic disease have worse outcomes.
  • Novel therapeutic agents are needed for high-risk osteosarcoma patient populations.