Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The human thymus during aging.

B F Haynes1, G D Sempowski, A F Wells

  • 1Department of Medicine, Duke University Arthritis Center, Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA. hayne002@mc.duke.edu

Immunologic Research
|May 8, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells.

Mucosal immunology·2015
Same author

In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy.

European journal of pain (London, England)·2015
Same author

Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women.

Mucosal immunology·2014
Same author

HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life.

Mucosal immunology·2013
Same author

Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants.

Journal of virology·2009
Same author

Immunosenescence of ageing.

The Journal of pathology·2007
Same journal

Emapalumab plus conventional therapy with or without ruxolitinib for pediatric hemophagocytic lymphohistiocytosis: a single center retrospective study.

Immunologic research·2026
Same journal

Immunological spectrum in patients with thymoma: beyond good syndrome.

Immunologic research·2026
Same journal

Microbiome immune crosstalk in Sjögren's syndrome: mechanistic insights and translational perspectives.

Immunologic research·2026
Same journal

Immune checkpoint inhibitor-induced myasthenia gravis and myocarditis: a fatal immune-related adverse event.

Immunologic research·2026
Same journal

TRIM28 and TRIM32: multifaceted regulators of innate immunity and antiviral defence.

Immunologic research·2026
Same journal

Decoding PANoptosis: Crosstalk of cell death pathways in immunity and inflammation.

Immunologic research·2026
See all related articles

The adult thymus produces new T cells, crucial for T cell immunity. Research reviews human thymic aging to improve T cell immune reconstitution strategies.

Area of Science:

  • Immunology
  • Developmental Biology

Background:

  • The thymus is essential for establishing T cell immunity, particularly in fetal development.
  • DiGeorge Syndrome, characterized by thymus absence, results in severe T cell deficiencies.
  • The capacity of the adult thymus to produce new T cells has been historically unclear due to a lack of direct assays.

Purpose of the Study:

  • To review research on human thymic aging conducted at Duke University School of Medicine.
  • To discuss the implications of thymic aging for developing strategies for T cell immune reconstitution in humans.

Main Methods:

  • This section is a review of existing research, not an experimental study.
  • Focuses on analyzing data and findings related to human thymic aging.

Related Experiment Videos

Main Results:

  • The adult thymus retains the capacity to generate new T cells, although this function may decline with age.
  • Understanding thymic aging is critical for addressing age-related immune decline.

Conclusions:

  • The adult thymus plays a role in maintaining T cell immunity throughout life.
  • Strategies for T cell immune reconstitution can be informed by studying thymic aging.
  • Further research into thymic function is needed to optimize immune therapies.