Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exchange transfusion for severe malaria.

S Alfandari1, G Dixmier, B Guery

  • 1Dept of Infectious Diseases and Intensive Care, Centre Hospitalier, Tourcoing, France. alfandari@nordnet.fr

Infection
|May 8, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Severe acute respiratory syndrome].

Medecine et maladies infectieuses·2024
Same author

Observation of New Ω_{c}^{0} States Decaying to the Ξ_{c}^{+}K^{-} Final State.

Physical review letters·2023
Same author

Measurement of the Ratios of Branching Fractions R(D^{*}) and R(D^{0}).

Physical review letters·2023
Same author

Measurement of the Prompt D^{0} Nuclear Modification Factor in p-Pb Collisions at sqrt[s_{NN}]=8.16  TeV.

Physical review letters·2023
Same author

Measurement of the Branching Fractions B(B^{0}→pp[over ¯]pp[over ¯]) and B(B_{s}^{0}→pp[over ¯]pp[over ¯]).

Physical review letters·2023
Same author

Measurement of the Time-Integrated CP Asymmetry in D^{0}→K^{-}K^{+} Decays.

Physical review letters·2023
Same journal

Double agent: how Escherichia coli switches from commensal to pathogen in the urinary tract infection.

Infection·2026
Same journal

Metagenomic next-generation sequencing assists in identifying neurosyphilis: a case series.

Infection·2026
Same journal

Chlamydia trachomatis infection among women with spontaneous abortion in Uganda: burden, clinical presentation, and associated factors in a hospital-based cross-sectional study.

Infection·2026
Same journal

Performance of ultra-sensitive electrochemiluminescence LAM assay for diagnosing tuberculosis in HIV-negative individuals: a multicentre, prospective diagnostic study.

Infection·2026
Same journal

Prehospital blood cultures in suspected sepsis: no need to wait until hospital arrival!

Infection·2026
Same journal

Epidemiological trends of invasive Streptococcus pyogenes infections in Catalonia, 2022-2024: a two-year analysis.

Infection·2026
See all related articles

Exchange transfusion (ET) may benefit severe falciparum malaria patients with very high parasitemia. This study suggests ET could be considered in critical cases despite chemotherapy, showing a lower death rate in high parasitemia patients.

Area of Science:

  • Tropical Medicine
  • Hematology
  • Infectious Diseases

Background:

  • Exchange transfusion (ET) is a debated ancillary treatment for severe falciparum malaria.
  • Severe malaria poses significant mortality risks, necessitating effective interventions.

Purpose of the Study:

  • To evaluate the efficacy of exchange transfusion as an ancillary treatment in severe falciparum malaria.
  • To compare outcomes between patients treated with and without ET.

Main Methods:

  • Retrospective analysis of severe malaria cases treated between 1991 and 1998.
  • Comparison of nine ET cases with 12 control patients matched for parasitemia.

Main Results:

  • No significant difference in overall mortality between ET and control groups.

Related Experiment Videos

  • A significantly lower death rate was observed in ET patients with parasitemia > 30% (0/4 vs. 3/3).
  • ET patients were older on average, but other baseline characteristics were similar.

    • Conclusions:

    • Exchange transfusion may be a life-saving intervention for severe falciparum malaria patients with extremely high parasitemia.
    • Consideration of ET is warranted in severe malaria cases with high parasite counts, severity criteria, or clinical deterioration despite standard treatment.