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The natriuretic peptides: universal volume controllers.

H M Abdulla1

  • 1University of South Florida and James A. Haley VA Hospital, Division of Nephrology and Hypertension, Tampa, Florida 33612, USA. symbolic1@netscape.edu

Medical Hypotheses
|May 8, 2001
PubMed
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Natriuretic peptides, including atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), regulate fluid volumes. These peptides control intravascular, cerebrospinal fluid, and even individual cell volumes.

Area of Science:

  • Physiology
  • Endocrinology
  • Cardiovascular Research

Background:

  • Atrial natriuretic peptide (ANP) discovery revealed its role in fluid balance.
  • Several related natriuretic peptides, such as brain natriuretic peptide (BNP), have since been identified.
  • These peptides are implicated in regulating various bodily fluid volumes.

Purpose of the Study:

  • To explore the broader roles of natriuretic peptides beyond intravascular volume control.
  • To investigate the function of natriuretic peptides in conditions like increased intraocular and intracranial pressure.
  • To understand the cellular-level effects of natriuretic peptides.

Main Methods:

  • Literature review of studies on natriuretic peptides.
  • Analysis of peptide levels in various physiological and pathological conditions.

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  • Examination of the cellular mechanisms of natriuretic peptide action.

    • Main Results:

    • ANP demonstrates natriuretic and diuretic properties, managing intravascular volume.
    • Elevated ANP levels correlate with increased intraocular pressure and biliary obstruction.
    • BNP levels increase with elevated intracranial pressure, suggesting a role in cerebrospinal fluid regulation.
    • ANP influences individual cell size, indicating a role at the cellular level.

    Conclusions:

    • Natriuretic peptides are crucial regulators of intravascular volume.
    • These peptides also modulate cerebrospinal fluid volume and intraocular pressure.
    • Natriuretic peptides act as broad modulators of cavity volumes, extending to cellular volume control.