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Regional cerebral blood flow in patients suffering from post-traumatic stress disorder
1Department of Nuclear Medicine and Ludwig Boltzmann Institute of Nuclear Medicine, Vienna, Austria. siroos.mirzaei@nuk.wil.magwien.gv.at
Objective:
The aim of the study was to determine whether regional cerebral blood flow in survivors of torture suffering from post-traumatic stress disorder (PTSD) differed significantly from that in healthy controls.
Method:
We examined the cerebral regional distribution of 99m-technetium-hexamethylpropyleneamineoxime (HMPAO) using single photon emission computed tomography (SPECT) in 8 patients and in 8 healthy controls. A semi-quantitative analysis was performed in which symmetrical regions of interest (ROI) were drawn in all subjects.
Results:
Regional blood flow was markedly more heterogeneous in patients suffering from PTSD than in healthy controls. The differences are significant.
Conclusion:
Severe psychological trauma induced by torture can cause neurobiologic alterations that may contribute, even years after the original trauma, to a number of complaints commonly expressed by patients suffering from PTSD.