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Related Experiment Videos

Pyogenic abscesses and parasitic diseases.

J R Lambertucci1, A A Rayes, J C Serufo

  • 1Serviço de Doenças Infecciosas e Parasitárias, Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. lamber@net.em.com.br

Revista Do Instituto De Medicina Tropical De Sao Paulo
|May 8, 2001
PubMed
Summary

Parasitic infections can shift the immune response, increasing susceptibility to secondary bacterial and fungal infections like liver abscesses. Treating parasitic diseases may prevent severe superinfections.

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Tropical Medicine

Background:

  • Parasitic infections can alter host immune responses, potentially increasing vulnerability to other pathogens.
  • A shift from T helper 1 to T helper 2 immunity is associated with detrimental effects like granuloma formation and eosinophilia.

Observation:

  • Patients with schistosomiasis and elevated Immunoglobulin E (IgE) show increased risk of pyogenic liver abscesses when bacteremic with Staphylococcus aureus.
  • Associations between Salmonella and Schistosoma mansoni, and between Toxocara infection and pyogenic abscesses (liver and muscle), have been documented.

Findings:

  • Parasitic infections that induce a T helper 2 immune response may predispose hosts to severe bacterial and fungal superinfections.
  • Specific parasitic diseases like schistosomiasis and toxocariasis are linked to the development of pyogenic abscesses.

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Implications:

  • Understanding these associations may explain high bacterial disease morbidity in tropical regions.
  • Universal treatment of parasitic diseases could be a strategy to reduce the burden of bacterial and fungal superinfections.