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Intraadrenal mechanisms of DHEA regulation: a hypothesis for adrenopause
1Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892-1583, USA. alescis@mail.nih.gov
Abstract:
Dehydroepiandrosterone (DHEA) and its sulfate metabolite DHEAS are the major androgens secreted by the human adrenal gland. The specific control of these hormones remains unclear. While ACTH is a potent stimulator of DHEA secretion, other factors both systemic and local have been involved in adrenal androgen control. Here we review the extra and intraadrenal regulation of DHEA and propose a hypothetical model for adrenal senescence.